The Fly (1986), which
is actually a remake of a 1958 movie, starred Jeff Goldblum and Gena Davis (The Fly 2 was released in
1989). In this movie, scientist Seth Brundle (Goldblum) is in the process of developing a teleportation
device (like Star Trek). During a human test
trial, using himself as the subject, a fly gets into the tele-pod with him. Their DNA is subsequently fused,
and Brundle literally turns into a fly.